Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo® TQ-XS offers:
StepWave XS™ ion guide that provides increased sensitivity for challenging compounds.
Enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible.
Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users.
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PERFORMANCE SPECIFICATIONS
| Acquisition modes | Full scan MS Scanning ion product (enhanced with ScanWave) Scanning of precursor ions Constant loss sweep of neutral fragments Selected ion (SIR) Multi-reaction monitoring (MRM) Full scan and simultaneous MRM (RADAR) |
| Scan modes of study | Full scan MS data acts as an automatic trigger for the acquisition of improved product ion spectra with ScanWave. The scanning data of precursor ions act as an automatic activator for the acquisition of improved product ion spectra with ScanWave. The constant loss scanning data of neutral fragments act as an activator for the acquisition of improved product ion spectra with ScanWave. |
| Product Ion Confirmation Mode | The MRM data act as an automatic trigger for the acquisition of (PIC) |
| RADAR | An acquisition mode that provides a large amount of information and allows you to obtain extremely specific quantitative data of the compounds as a target, while you can view all other components. |
| Mass Range | 2 to 2048 m/z |
| Scan speed | Up to 20,000 Da / s Examples of acquisition speeds that can be achieved: |
| Mass stability | The mass assignment will be within +/- 0.05 Da for a period of 24 hours (the instrument should be used in accordance with the laboratory environmental guidelines described in the Xevo TQ-XS Installation Preparation Guide). |
| Linearity of response | The linearity of the response as a function of the concentration of the sample, for a specific compound, is six orders of magnitude from the limit of detection. |
| Polarity switching time | 15 ms to toggle between positive and negative ionization modes |
| MS to MS/MS switching time | 3 ms |
| ESCi mode switching time | 20 ms to switch between ESI and APCI |
| MRM acquisition rate | Maximum acquisition speed of 500 MRM data points per second; Minimum dwell time of 1 ms per MRM channel; Minimum phase shift between 1ms channels |
| Channel superposition | The overlap between channels between two MRM transitions, acquired using an MRM dwell time of 1 ms and a time lag between channels of 1 ms, is less than 0.01%. |
| Number of MRM channels | Up to 32 768 MRM channels (1024 functions, 32 channels per function) can be controlled in a single acquisition; Up to 1024 MRM channels when operating in GLP / Safe mode (32 functions, 32 channels per function). |
| Mass resolution | Automatically adjusted (IntelliStart) to the desired resolution; (0.50 Da, 0.75 Da or 1.00 Da for FWHM) |
| MRM sensitivity (ESI+) | A 1 pg column injection of reserpine will provide a chromatographic signal-to-noise ratio greater than 500,000: 1 from unmalted original data (gradient separation, mobile phase flow of LC of 0.4 mL / min, transition MRM 609 > 195 m / z). |
| MRM sensitivity (ESI-) | A column injection of 1 pg chloramphenicol will provide a chromatographic signal-to-noise ratio greater than 500,000: 1 from unmalted original data (gradient separation, LC mobile phase flow of 0.8 mL / min, transition MRM 321 > 152 m / z). |
| MRM sensitivity (APCI+) | A 1-pg column injection of 17-α-hydroxyprogesterone will provide a chromatographic signal-to-noise ratio greater than 300: 1 from unmalted original data (gradient separation, mobile LC phase flow of 0.8 mL / min, Transition MRM 331> 109 m / z). |
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